abstract：Objectives:Traumatic brain injury (TBI) is one of the main causes of intellectual and cognitive disabilities. Clinically, it is essential to limit the development of cognitive impairment after TBI. In the present study, the neuroprotective effects of gallic acid (GA) on neurological score, memory, long-term potentiatio...

journal_title：Iranian journal of basic medical sciences

authors： Mirshekar MA,Sarkaki A,Farbood Y,Gharib Naseri MK,Badavi M,Mansouri MT,Haghparast A

更新日期：2018-10-01 00:00:00

abstract：Objectives:Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hD...

journal_title：Iranian journal of basic medical sciences

authors： Pourgonabadi S,Ghorbani A,Tayarani Najarn Z,Mousavi SH

更新日期：2018-09-01 00:00:00

abstract：Objectives:Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic...

journal_title：Iranian journal of basic medical sciences

authors： Havakhah S,Sankian M,Kazemzadeh GH,Sadri K,Bidkhori HR,Naderi-Meshkin H,Ebrahimzadeh Bideskan A,Niazmand S,Bahrami AR,Khajavi Rad A

更新日期：2018-08-01 00:00:00

abstract：Objectives:Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment and homing capacity of HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo expansion and homing capaci...

journal_title：Iranian journal of basic medical sciences

authors： Mohammadali F,Abroun S,Atashi A

更新日期：2018-07-01 00:00:00

abstract：Objectives:We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods:I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was per...

journal_title：Iranian journal of basic medical sciences

authors： Gholampour F,Khangah L,Vatanparast J,Karbalaei-Heidari HR,Owji SM,Bahaoddini A

更新日期：2018-06-01 00:00:00

abstract：Objectives:Weight gain and metabolic disturbances such as dyslipidemia, are frequent side effects of second-generation antipsychotics, including olanzapine. This study examined the metabolic effects of chronic olanzapine exposure. In addition, we investigated the hepatic fatty acid effects of olanzapine in female C57BL...

journal_title：Iranian journal of basic medical sciences

authors： Hou PH,Chang GR,Chen CP,Lin YL,Chao IS,Shen TT,Mao FC

更新日期：2018-05-01 00:00:00

abstract：Objectives:Cholinergic neurons are important neurons in the Pedunculopontine tegmental nucleus (PPT). In this study, nicotinic receptor of the PPT in central cardiovascular regulation in the anesthetized rat was evaluated. Materials and Methods:Saline, acetylcholine (Ach; doses: 90 and 150 nmol), hexamethonium (Hexa; ...

journal_title：Iranian journal of basic medical sciences

authors： Nikyar T,Hosseini M,Niazmand S,Shafei MN

更新日期：2018-04-01 00:00:00

abstract：Objectives:Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH's neurodegenerativ...

journal_title：Iranian journal of basic medical sciences

authors： Moshiri M,Hosseiniyan SM,Moallem SA,Hadizadeh F,Jafarian AH,Ghadiri A,Hoseini T,Seifi M,Etemad L

更新日期：2018-04-01 00:00:00

abstract：Objectives:Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reported to be associated with many inflammatory mediators of PAH. This study aimed to evaluate the eff...

journal_title：Iranian journal of basic medical sciences

authors： Gao L,Liu J,Hao Y,Zhao Z,Tan H,Zhang J,Meng N,Zheng Q,Wang Z,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：Objectives:Radiotherapy is one of the most effective modalities of cancer therapy, but clinical responses of individual patients varies considerably. To enhance treatment efficiency it is essential to implement an individual-based treatment. The aim of present study was to identify the mechanism of intrinsic apoptosis ...

journal_title：Iranian journal of basic medical sciences

authors： Azimian H,Dayyani M,Toossi MTB,Mahmoudi M

更新日期：2018-03-01 00:00:00

abstract：Objectives:Several lines of evidence showed that minocycline possesses antioxidant and anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in rats subjected to chronic constriction injury (CCI). Materials and Methods:In this study four groups (n = 6-8) of rats were used as follows:...

journal_title：Iranian journal of basic medical sciences

authors： Abbaszadeh A,Darabi S,Hasanvand A,Amini-Khoei H,Abbasnezhad A,Choghakhori R,Aaliehpour A

更新日期：2018-02-01 00:00:00

abstract：Objectives:Heparin-binding hemagglutinin (HBHA), a mycobacterial cell surface protein, mediates adhesion to nonphagocytic cells and the dissemination of Mycobacterium tuberculosis (M. tuberculosis) from the site of primary infection. Superior expression systems are required to obtain abundant M. tuberculosis proteins f...

journal_title：Iranian journal of basic medical sciences

authors： Teng X,Chen X,Zhu K,Xu H

更新日期：2018-02-01 00:00:00

abstract：:Klotho (KL) encodes a single-pass transmembrane protein and is predominantly expressed in the kidney, parathyroid glands, and choroid plexus. Genetic studies on the KL gene have revealed that DNA hypermethylation is one of the major risk factors for aging, diseases, and cancer. Besides, KL exerts anti-inflammatory and...

journal_title：Iranian journal of basic medical sciences

authors： Xuan NT,Hai NV

更新日期：2018-01-01 00:00:00

abstract：Objectives:The monitoring of cancer treatment response to chemotherapy is considered an essential strategy for follow-up of patients. The aim of this study was to evaluate the use of 99mTc-glucarate as a radiotracer for in vivo quantification and visualization of necrotic area and therapeutic effect of paclitaxel in ov...

journal_title：Iranian journal of basic medical sciences

authors： Sadeghi H,Rahmanian N,Amiri FT,Amirfakhrian H,Abedi SM,Hosseinimehr SJ

更新日期：2018-01-01 00:00:00

abstract：Objective:The role of growth factors, including vascular endothelial growth factor of activated omentum on mitosis is clearly known, though not on all the aspects of in vitro oocyte maturation. This study was designed to assess the effect of activated-omental extract (AOE) on in vitro maturation (IVM) of rat cumulus-oo...

journal_title：Iranian journal of basic medical sciences

authors： Mesbah F,Pracha AD,Talaei-Khozani T,Bahmanpour S

更新日期：2017-12-01 00:00:00

abstract：Objectives:In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods:Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally ...

journal_title：Iranian journal of basic medical sciences

authors： Sudjarwo SA,Eraiko K,Sudjarwo GW,Koerniasari

更新日期：2017-11-01 00:00:00

abstract：Objectives:This study was to investigate the antihyperlipidemic and antioxidant effect of total flavonoid extract from Actinidiakolomikta (TFAK) in hyperlipidemia induced by a high-fat diet. Materials and Methods:Male SD rats were randomly divided into 6 groups: normal group, model (hyperlipidemic diet) group, hyperli...

journal_title：Iranian journal of basic medical sciences

authors： Yu Z,Xu H,Yu X,Sui D,Lin G

更新日期：2017-10-01 00:00:00

abstract：:Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to...

journal_title：Iranian journal of basic medical sciences

authors： Babatunde KA,Najafi A,Salehipour P,Modarressi MH,Mobasheri MB

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:In previous studies, researchers observed that doxepin could improve cognitive processes and has protective effects on the central nervous system. Thus, this study was designed to analyze the effects of doxepin on β-amyloid (Aβ)-induced memory impairment and neuronal toxicity in rat and to explore the underl...

journal_title：Iranian journal of basic medical sciences

authors： Bu J,Zu H

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. MATERIALS AND METHODS:...

journal_title：Iranian journal of basic medical sciences

authors： Kashani IR,Chavoshi H,Pasbakhsh P,Hassani M,Omidi A,Mahmoudi R,Beyer C,Zendedel A

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Particulate matter (PM) exposure can promote cardiac ischemia and myocardial damage. The effects of PM10 on hemodynamic parameters, lipid peroxidation, and infarct size induced by ischemia-reperfusion injury and the protective effects of vanillic acid (VA) in isolated rat heart were investigated. MATERIALS ...

journal_title：Iranian journal of basic medical sciences

authors： Radmanesh E,Dianat M,Badavi M,Goudarzi G,Mard SA

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Determination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and 1HNMR spectroscopy with chemometric techniques. The stages of colon cancer were detected from patients' sera using 1HNMR. MATERIALS AND METHODS:Five ml blood was ...

journal_title：Iranian journal of basic medical sciences

authors： Vahabi F,Sadeghi S,Arjmand M,Mirkhani F,Hosseini E,Mehrabanfar M,Hajhosseini R,Iravani A,Bayat P,Zamani Z

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:Recently, we showed that some new synthetic compounds structurally related to cilostamide (4-(1,2-dihydro-2-oxoquinolin-6-hydroxy)- N-cyclohexyl-N-methylbutanamide), a selective phosphodiesterase 3 (PDE3) inhibitor, produce inotropic effect comparable to that of IBMX (3-isobutyl-1-methylxanthine), a non-sele...

journal_title：Iranian journal of basic medical sciences

authors： Hosseini A,Shafiee-Nick R,Sadeghian H,Parsaee H

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:Pseudomonas aeruginosa is a Gram-negative and aerobic rod bacterium that displays mucoid and non-mucoid phenotype. Mucoid strains secrete alginate, which is the main agent of biofilms in chronic P. aeruginosa infections, show high resistance to antibiotics; consequently, the biological disruption of mucoid P...

journal_title：Iranian journal of basic medical sciences

authors： Ghadam P,Akhlaghi F,Ali AA

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Various studies have shown that the diabetes is associated with liver failure. The objective of this study was determining the effects of Berberis vulgaris fruit on histopathological and biochemical markers of liver in diabetic rats. MATERIALS AND METHODS:In this experimental study, 60 male Wistar rats weig...

journal_title：Iranian journal of basic medical sciences

authors： Rahimi-Madiseh M,Karimian P,Kafeshani M,Rafieian-Kopaei M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic d...

journal_title：Iranian journal of basic medical sciences

authors： Wang H,Li C,Li J,Zhu Y,Jia Y,Zhang Y,Zhang X,Li W,Cui L,Li W,Liu Y

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. MATERIALS AND METHODS:Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and mo...

journal_title：Iranian journal of basic medical sciences

authors： Abnosi MH,Golami S

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:Prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (NaHS) but effect of NaHS on mRNA expression of prostaglandin E2 receptors (EP1, 3-4; EPs) has not been investigated. Therefore, this study designed to evaluate the effect of NaHS on mRNA expression of EPs receptors...

journal_title：Iranian journal of basic medical sciences

authors： Mard SA,Mahini S,Dianat M,Farbood Y

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:The Muller cell is the principal glial cell of the vertebrate retina. The expression of Glial fibrillary acidic protein (GFAP) in the Muller cells was used as a cellular marker for retinal damage. This study was done to evaluate the effect of gestational diabetes on retinal Muller cells in rat's offspring. ...

journal_title：Iranian journal of basic medical sciences

authors： Tabasi A,Ghafari S,Mehdizadeh M,Shekari MA,Golalipour MJ

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:To study the effect of low-frequency vibration on bone marrow stromal cell differentiation and potential bone repair in vivo. MATERIALS AND METHODS:Forty New Zealand rabbits were randomly divided into five groups with eight rabbits in each group. For each group, bone defects were generated in the left humer...

journal_title：Iranian journal of basic medical sciences

authors： He S,Zhao W,Zhang L,Mi L,Du G,Sun C,Sun X

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Previous studies showed that skeletal muscle microcirculation was reduced in chronic heart failure. The aim of this study was to investigate the effects of endurance training on capillary and arteriolar density of fast and slow twitch muscles in rats with chronic heart failure. MATERIALS AND METHODS:Four we...

journal_title：Iranian journal of basic medical sciences

authors： Ranjbar K,Ardakanizade M,Nazem F

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported...

journal_title：Iranian journal of basic medical sciences

authors： Arbabi E,Hamidi G,Talaei SA,Salami M

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Acquisition of TNF-α resistance plays role in the onset and growth of malignant tumors. Previous studies have demonstrated that MCF-7 cell line and its doxorubicin resistant variant MCF-7/Adr are resistant against the cytotoxic effects of TNF-α. In this study, we investigated the role of Akt activation in re...

journal_title：Iranian journal of basic medical sciences

authors： Ghandadi M,Mohammadi A,Behravan J,Abnous K,Haj-Ali N,Gharaee ME,Mosaffa F

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. MATERIALS AND METHODS:Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group wen...

journal_title：Iranian journal of basic medical sciences

authors： Alimohammadi-Kamalabadi M,Eshraghian M,Zarindast MR,Aliaghaei A,Pishva H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (SLNs) containing Zataria multiflora essential oil (ZEO). MATERIALS AND METHODS:In this study, Z. multiflora essential oil-loaded solid lipid nanoparticles (ZE-SLNs) were prepared to improve its efficiency in c...

journal_title：Iranian journal of basic medical sciences

authors： Nasseri M,Golmohammadzadeh S,Arouiee H,Jaafari MR,Neamati H

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The purpose of the current study was to assess the feasibility of microspheres from biocompatible polymer for oral bioavailability (BA) enhancement of potent sulfonamide- type loop diuretic- Furosemide - which used in the treatment of congestive heart failure, caused edema, cirrhosis, renal disease and as an...

journal_title：Iranian journal of basic medical sciences

authors： Derakhshandeh K,Karimi M,Azandaryani AH,Bahrami G,Ghanbari K

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. Reprogramming-related transcription factors, also known as Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC), are also well-known oncogenes promoting cancer initiation, pr...

journal_title：Iranian journal of basic medical sciences

authors： Sahebi R,Malakootian M,Balalaee B,Shahryari A,Khoshnia M,Abbaszadegan MR,Moradi A,Javad Mowla S

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:Endometriosis is a complex gynecologic disease with unknown etiology. Noscapine has been introduced as a cancer cell suppressor. Endometriosis was considered as a cancer like disorder, The aim of present study was to investigate noscapine apoptotic effect on human endometriotic epithelial and stromal cells i...

journal_title：Iranian journal of basic medical sciences

authors： Khazaei MR,Rashidi Z,Chobsaz F,Khazaei M

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate the protective effects of total flavonoid extract from Coreopsis tinctoria Nutt. (CTF) against myocardial ischemia/reperfusion injury (MIRI) using an isolated Langendorff rat heart model. MATERIALS AND METHODS:Left ventricular developed pressure (LVDP) and the maximum rate of ri...

journal_title：Iranian journal of basic medical sciences

authors： Zhang Y,Yuan C,Fang H,Li J,Su S,Chen W

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:In food industry, the inhibition of tyrosinase is very important, because this enzyme catalyzes the oxidation of phenolic compounds found in fruits and vegetables into quinones, which contribute in undesirable color and taste of fruits and vegetables. Teucrium polium L. var. gnaphalodes (Lamiaceae), a wild-g...

journal_title：Iranian journal of basic medical sciences

authors： Boghrati Z,Naseri M,Rezaie M,Pham N,Quinn RJ,Tayarani-Najaran Z,Iranshahi M

更新日期：2016-08-01 00:00:00